We describe the best early treatment for Covid to date

Paxlovid Pill (art representative)

On behalf of Paxlovid, Pfizer is a new drug to treat Covid-19 early. The drug contains two main active ingredients.| Photo: Bigstock | plyushkin do

An alcohol of two vaccines prepared by Pfizer for Covid-19 has been included by the Ministry of Health in a standardized treatment. The drug, called Paxlovid, is given in tablets for the first five days of symptoms to prevent the respiratory virus from changing to a more severe form. In other words, Paxlovid is the Pfizer solution for early treatment.

For a month and a half, the drug was approved for emergency use. According to new guidelines from the Ministry, it should be available in SUS within six months for adults 65 years of age and older and / or those with weakened immune systems. The minimum age indicated to take it is 12 years, with a body weight of 40 kg.

BioNTech, Pfizer partner in developing mRNA antibody for Covid, was also involved in developing Paxlovid. In November, companies reported preliminary results with 774 patients showing that the drug reduced the risk of transmission to the deadly virus by 89%.

The results were most recently evaluated in December and reported in the journal New England Journal of Medicine in February. Contrary to what happened with Merck drug Molnupiravir, “mark” of Paxlovid for research reports was promising.

How does Paxlovid work?

The drug that makes up the drug has additional side effects. When SARS-CoV-2 enters the human cell, it induces itself to produce self-assembling products. One of the products is protein that needs to be cut into pieces in order to function. The virus has a specific molecular structure that leads to cutting – these shears prevent the action of nirmatrelvir, one of the products. Nirmatrelvir has been around since 2002, when it was developed by Pfizer for the Asian flu at the time, which was caused by a virus associated with the new virus-19.

Another component is ritonavir, developed with the goal of treatment with AIDS. Its role in Paxlovid is to prevent nirmatrelvir from being damaged by the liver before it can interfere with corona grafting. It is most important, because it protects the heart from chewing on a special drug other than nirmatrelvir, so the risk of interaction of the drug with other drugs is significant and treatment must be repeated.

Concerns have been raised not only about the efficacy of Paxlovid, but also about recovery from the disease when five days of drug administration have elapsed. Since this treatment directly fights infectious diseases, it works before the immune system can improve its own immunity, and when not present, there are still some effective treatments. sick enough for the disease to avenge.

In addition, efficacy was only known to those who were not vaccinated, who were included in this study. Vinay Prasad, a professor of infectious diseases and biostatistics at the University of California, San Francisco, and critic of closed-loop transmission measures, expressed concern that the Paxlovid consensus could be passed too quickly. the effects of the vaccine may vary.

Is Ivermectin Dead?

While the situation is still tense and facing strong protests in June 2021, the Gazette people pays attention to early treatment of Covid-19 by repeating over-the-counter drugs to treat other diseases. We have been given: ivermectin (vermifuge), budesonide (for asthma) and fluvoxamine (antidepressant). Of these, only ivermectin was problematic as a treatment for Covid, probably due to the particular political affiliation of its name, and then also due to the occurrence of fraud in the result of his interest.

After the revelation of fraudulent research with ivermectin, Scott Alexander, an American psychiatrist working in California and has been holding a research and culture blog for nine years, pored beyond the important evidence of drug use. Faced with studies agreeing to its effectiveness, such as Mahmud and colleagues, Alexander has speculated as to why ivermectin seems to work if it can rid people of the disease. whose presence could have had a major impact on the transformation of the Covid-19. This assumption is odd, because it thinks worms are more than true. More parsimonious is to show that there is some performance in ivermectin, although the evidence such as p value (an indication that the results of the research are credible and not a result of priority) does not necessarily capture it. Other past research experts have questioned the skepticism about the use of ivermectin for this purpose, such as Australian pathologist and physician Gideon Meyerowitz-Katz, angry. voice and cause doubt.

With the rise of antihistamines – whether the conflict is scientific or political – like Paxlovid, we may not be aware of how strictly ivermectin has helped.

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